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Wednesday, November 18, 2015
2nd floor Maxwell Dworkin Lounge
National University of Singapore, Singapore
& FIRC Institute of Molecular Oncology (IFOM), Milan, Italy
/E-mail: firstname.lastname@example.org /
Nuclear Mechanics of Genome Reprogramming*
Physico-chemical signals from the extracellular matrix impinge on cellular
geometry resulting in altered functional nuclear landscape and gene expression.
While these alterations regulate diverse biological processes including stem-
cell differentiation, developmental genetic programs and cellular homeostasis;
the biophysical principles underlying such control systems are unclear.
Using a multidisciplinary approach by combining high resolution optical imaging,
quantitative single-cell biophysics and functional genomics, our laboratory
investigates the principles underlying the coupling between nuclear mechanics
and genome regulation. I will describe our ongoing work that provides modular
links between cellular geometry and nuclear mechanics and its impact on 3D
organization of chromosomes and gene expression. Such optimized modular links
define the normal state of cells and these links are altered during diseases.
In this context, our studies will also have profound impact on developing
single- cell nuclear biomechanical markers in early disease diagnostics for
Shivashankar is currently the Deputy Director of Mechanobiology
Institute, National University of Singapore. Shivashankar's laboratory
is focused on understanding the role of cell geometry on nuclear
mechanics and genome regulation in living cells using a
multi-disciplinary approach. He carried out his PhD research at the
Rockefeller University (1994-1999) and Postdoctoral research at NEC
Research Institute, Princeton USA (1999-2000). He started his laboratory
at the National Center for Biological Sciences, TIFR- Bangalore, India
(2000-2009) before relocating to a tenured faculty position at the
National University of Singapore in 2009. His scientific awards include;
the Birla Science Prize (2006), The Swarnajayanthi Fellowship (2007) and
was elected to the Indian Academy of Sciences (2010). He Edited the
Methods in Cell Biology series book on ?Nuclear Mechanics and Genome
Regulation? (2010), Elsevier Press. More recently he Heads the Joint
Research Laboratory with FIRC Institute of Molecular Oncology (IFOM),
Milan, Italy and was appointed as an IFOM-NUS Chair Professor in 2014.